PMID

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Article Title

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Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.

Gifu University

Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.

University of Montpellier

Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates.

Academy of Sciences of The Czech Republic

Small-molecule activators of RNase L with broad-spectrum antiviral activity.

Lerner Research Institute

Synthesis, characterization, and biological properties of 8-azido- and 8-amino-substituted 2',5'-oligoadenylates.

Gunma University

Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine.

TBA

 

Synthesis and properties of 25 and 35 linked -oligoriboadenylates

TBA

5'-O-Dephosphorylated 2',5'-oligoadenylate (2-5A) with 8-methyladenosine at the 2'-terminus activates human RNase L.

Gifu University

Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.

Academy of Sciences of The Czech Republic

Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery.

Peking University Shenzhen Graduate School

Convergent synthesis of ribonuclease L-active 2',5'-oligoadenylate-peptide nucleic acids.

National Institute of Diabetes and Digestive Antd Kidney Diseases

2-Methyladenosine-Substituted 2',5'-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L.

Gifu University

Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.

TBA